Prof. Julie Makani (Principal Investigator)Prof. Makani a senior lecturer based at Muhimbili University of Health and Allied Sciences (MUHAS), which is the main clinical, academic and research centre in Tanzania. Her area of interest is haematology as a clinical area, with a focus on sickle cell disease (SCD). She is the PI for the Sickle Cell Programme and SPARCO.
Dr. Furahini Tluway (Project Manager)Dr. Tluway is Medical Doctor with 19 years of work experience. She holds a medical degree (MD) and Master of Public Health (MPH) from Muhimbili University College of Allied Sciences (MUHAS), (1996 and 2014 respectfully). She has previously worked as a medical doctor in Tanzania and Zimbabwe in different capacities and at different hospitals/health facilities. Furahini joined Muhimbili Wellcome Programe (MWP) - now Sickle Cell Program (MHP) in August 2014. Currently working for Sickle Cell Programme MUHAS as Programme Coordinator. She also coordinates SPARCO activities at the Consortium level and SickleGenAfrica (Tanzania site).
Prof. Solomon Ofori-Acquah (Advisor)Dr. Ofori-Acquah is an Associate Professor of Medicine and Human Genetics at the Universityof Pittsburgh. He is Director of the Center for Translational and International Hematology at the University’s Vascular Medicine Institute. He is Director and Project Leader of a number of NIH and Wellcome Trust research and training programs. His research is focused on the role and mechanism of extracellular heme in the pathobiology of sickle cell disease (SCD). He has developed a mouse model of acute chest syndrome that recapitulates the clinical, biological and pathological features of the condition in humans. His group is using this model to unravel the mechanism of lung injury in acute chest syndrome, and to test candidate drugs for their potential to prevent and treat this lung condition. He developed the concept of extracellular heme crisis in SCD, and defined free heme as a prototypical erythroid danger associated molecular pattern molecule that drives sterile inflammation in this disorder in the absence of infection. His research on chronic effects of heme is focused on the role and mechanism of the Nrf2 pathway in end-organ damage. His global health activities include co-directing a longitudinal observational study of biomarkers of organ damage in a large SCD cohort in Kumasi, Ghana, and as Director of the graduate course in Molecular Mechanisms of Human Genetic Diseases in the University of Ghana’s Wellcome Trust funded DELTAS Africa program.
Dr. Raphael Sangeda (Data Manager)Dr. Sangeda is a lecturer and Head of the Department of Pharmaceutical Microbiology at the MUHAS node. Raphael graduated with a B. Pharm from Dr MGR Medical University, Chennai, India in 1998. In 2005, he obtained his MSc in Medical Microbiology at Jomo Kenyata University of Agriculture and Technology. In 2005 he joined Katholieke Universiteit Leuven, now KU Leuven, in Belgium where he graduated in M. Pharm (2006), MSc. Bioinformatics (2008) and PhD (2013) on the use of Bioinformatics approaches to predict HIV drug resistance. His interest at MWP includes the use of Genome Wide Association Studies (GWAS) in investigating the ‘Genetic epidemiology of Human Immunodeficiency Virus, Hepatitis B virus and Hepatitis C virus infections in individuals with Sickle Cell Disease.
Nkwaya E Kipilyango (Finance Admin)
Bakari Mbaga (Admin Assistant)
Mr. Frank Makundi (IT specialist)
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